Animal Models of Typical Heterotopic Ossification

Animal Models of Typical Heterotopic Ossification

Heterotopic ossification (HO) is the formation of marrow-containing bone outside of the normal skeleton. Acquired HO following traumatic events is a common and costly clinical complication. In contrast, hereditary HO is rarer, progressive, and life-threatening. Substantial effort has been directed towards understanding the mechanisms underlying HO and finding efficient treatments. However, one ...

Animal models for acquired heterotopic ossification.

Heterotopic ossification (HO), the ectopic formation of bone in soft tissues, is a relevant musculoskeletal disorder that, by reduction of range of motion, may lead to significant impairment of quality of live. HO can either be acquired or hereditary. Acquired HO is seen most often after hip prosthetic surgery and pelvic trauma. In contrast, hereditary HO is commonly observed in the axial skele...

Heterotopic Ossification

Heterotopic Ossification

Heterotopic ossification is a complicated and significant medical problem characterized by abnormal growth of bone in soft tissues. It occurs most commonly around a joint following surgery or trauma and is one of only a few benign conditions commonly treated with radiation therapy. In its severe form, the condition causes pain, loss of function, and restricted range of motion in the affected jo...

Progression of Heterotopic Ossification around the Elbow after Trauma

 Background: This study addresses the null hypothesis that there is no expansion of heterotopic ossification (HO) in the elbow beyond what can be seen early on.   Methods: The area of HO was measured on lateral radiographs of 38 consecutive patients that had operative treatment of HO between 2000 and 2013. Measurements from radiographs obtained between 3 to 7 weeks were compared to measurements...